关键词: 乳腺肿瘤, 免疫组织化学

Abstract: Objective To explore the effects of XIAP on carcinogenesis and progression of breast cancer.Methods The expressions of XIAP in the tissues of normal mammary (96 cases), cystic hyperplasia mammary (56 cases), atypical hyperplasia mammary (12 cases),and breast cancer (119 cases) were evaluated by SP immunohistochemistry. The relationships between XIAP expression and the pathologically biological features of breast cancer were assessed.Results The positive rates of XIAP in the tissues of normal mam mary, cystic hyperplasia mammary, atypical hyperplasia mammary and breast cancer were 4.2%(4/96), 5.4%(3/56),42.7%(5/12) and 72.3%(86/119), respectively. The positive rates in the last two groups were higher than those in the former two groups (P<0.05). XIAP was more expressed in the infiltrative non-special breast cancer (82.0%,73/89) than in the special and early stage infiltrative breast cancer (37.5%,3/8)(P<0.05). Expression of XIAP was increased in breast cancer with lymph node metastasis although the difference was not significant (P>0.05). Conclusion Overexpression of XIAP is common in carcinogenesis and progression of breast cancer. Altered expression of　XIAP　may contribute to carcinogenesis and progression of breast cancer by inhibiting apoptosis, its overexpression indicates worse prognosis.

Key words: breast neoplasms, immunohistochemisty