氧化苦参碱对正常及乌头碱诱发心律失常大鼠动作电位的影响

doi:吉林省科技厅资助课题

氧化苦参碱对正常及乌头碱诱发心律失常大鼠动作电位的影响

陈霞¹，李英骥²，葛静岩²，张文杰²，钟国赣^2*

1. 吉林大学基础医学院药理学教研室，吉林长春130021；2. 吉林大学基础医学院生理学教研室，吉林长春130021

收稿日期:2004-03-31 修回日期:1900-01-01 出版日期:2004-09-28 发布日期:2004-09-28
通讯作者: 钟国赣

Effects of oxymatrine on action potential in normal ratsand arrhythmic rats induced by aconitine

CHEN Xia¹,LI Ying-ji²,GE Jing-yan²,ZHANG Wen-jie²,ZHONG Guo-gan^2*

1.Department of Pharmacology,School of Basic Medical Sciences,Jilin University,Changchun 130021，China；2.Department of Physiology,School of Basic MedicalSciences,Jilin University, Changchun 130021，China

Received:2004-03-31 Revised:1900-01-01 Online:2004-09-28 Published:2004-09-28
Contact: ZHONG Guo-gan

摘要/Abstract

摘要： 目的：观察氧化苦参碱(OMT)对正常及乌头碱诱发大鼠心律失常模型动作电位(AP)的影响。方法：采用悬浮微电极技术记录大鼠在体心室肌细胞的动作电位。结果：给予3、15和30 mg•kg^-1的OMT能剂量依赖性地延缓乌头碱所致大鼠心律失常的发生，静脉给予30 mg•kg^-1的OMT能减小AP的幅值，缩短APD₅₀和APD₉₀，降低V_max。结论：OMT对心肌细胞AP的影响可能为其抗心律失常作用机制之一。

关键词: 药理学, 心律失常, 药物疗法, 电生理学

Abstract: Objective To observe the effects of oxymatrine on action potential in normal rats and arrhythmic rats induced by aconitine. Methods Action potential of ventricular myocytes of rats were recorded by suspended electrods. Results The oxymatrie at different doses(5,15, and 30 mg•kg^-1) could delay the onset time of the arrhythmia induced by aconitine in dose-dependent manner in rats. After intravenous adminstration of oxymatrine(30 mg•kg^-1) ,the average amplitude of the action potentials was reduced; the action potentials duration, measured at the 50% and 90% repolarization levels, was shortened； and maximum upstroke velocity of action potential was significantly decreased. Conclusion These results suggest that oxymatrine may inhibit cardiac sodium current.

Key words: pharmacology, arrhythmia, drug therapy, electrophysiology

中图分类号:

R285.5

陈霞，李英骥，葛静岩，张文杰，钟国赣. 氧化苦参碱对正常及乌头碱诱发心律失常大鼠动作电位的影响[J]. J4, 2004, 30(5): 704-706.

CHEN Xia,LI Ying-ji,GE Jing-yan,ZHANG Wen-jie,ZHONG Guo-gan. Effects of oxymatrine on action potential in normal ratsand arrhythmic rats induced by aconitine[J]. J4, 2004, 30(5): 704-706.

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