A total of 106 patients with the first IVF-ET were randomly assigned into control group （n=53） and multiple-dose GnRH-a group （n=53）. The patients in control group were given standard luteal support treatment， while the patients in multiple-dose GnRH-a were given standard luteal support plus GnRH-a at day 2， day 5 and day 8 after egg retrieval. The pregnancy outcomes including pregnancy rates， clinical pregnancy rates and live birth rates of the patients were compared between two groups， and the delivery outcomes included premature birth rate， low-birth weight birth rate and birth defect rate of the patients were compared between two groups. The serum progesterone levels of the patients in two groups were detected. The offsprings of the patients were followed up，and the Bayley Infant Development Scale （Bayley Ⅲ） and Child Behavior Checklist （CBCL） were used to evaluate the exercise， cognitive abilities， language and behavioral development of the children.

The pregnancy rate， clinical pregnancy rate， and live birth rates of the patients in multiple-dose GnRH-a group were statistically higher than those in control group （P<0.05）. There were no significant differences in the rates of premature birth， low-birth weight and birth defects of the patients between two groups （P>0.05）.On the 14th day after embryo implantation， the serum progesterone level of the patients in multiple-dose GnRH-a group was significantly higher than that in control group （P<0.05）.The subgroup analysis results showed that on the 14th day after embnyo implantation，the serum progesterone levels of the pregnancy and non-pregnant patients in multiple-dose GnRH-a group were significantly higher than those in control group， respectively （P<0.05）.There were no significant differences in Bayley Ⅲ score and CBCL score of the patients between two groups at 24th month （P>0.05）.

Addition of multiple-dose GnRH-a to standard lutal support treatment can achieve better pregnancy outcomes with sustained better safety.