The clinical data of one patient with severe invasive periodontitis resulted in loosening and disengagement of teeth were collected. After periodontium-orthodontium-implant-prosthesis multidisciplinary combined treatment， the bleeding on probing （BOP）， probing depth （PD）， attachment loss （AL） and implant osseointegration indexes of the patient were observed to determine the clinical repair effect；at the same time， literature review was conducted.

The patient， female， was conscious of the loosening and discomfort of the front and rear mandibular teeth in Jan. 2016； recently， the loosening became worse and she dared not bite on the hard objects. The clinical examination found that the patient’s oral hygiene was poor； the gingival of 31， 35， 36， 37， 41 were dark red； BOP （+）； PD 5－7 mm； AL 3－5 mm； teeth mobility： Ⅲ°.The clinical diagnosis was severe invasive periodontitis. First， periodontal treatment was performed to eliminate inflammation. After the inflammation was obviously eliminated， the affected teeth loosened by Ⅲ° were removed. In order to close the anterior teeth space， develop the lower anterior teeth and leave space for implantation， the patient was treated with orthodontic treatment. Finally， the bone defect was repaired by guided bone regeneration （GBR）. When the periodontal soft and hard tissues grew well and the alveolar ridge was plump， implant restoration was performed. During the whole treatment process， the plaque was strictly controlled， the chewing function of the patient was restored， and the anticipated aesthetic effect was achieved. One year later， the patient’s oral hygiene was good， the implant position was stable， and the radiographic examination showed no loss of bone around the implant.The gingival was pink and had not obvious inflammation.

Multidisciplinary combined treatment of the invasive periodontitis patients can not only recover the masticatory function of the patient， but also achieve the effect of aesthetic restoration.