CXC趋化因子受体3对神经系统疾病发生发展影响的研究进展

doi:10.13481/j.1671-587X.20240535

Abstract

Abstract:

Chemokines and their receptors play crucial roles in nervous system diseases， among which the CXC chemokine receptor 3 （CXCR3） is an important mediator of intercellular communication. CXCR3 not only participates in inflammatory chemotaxis and malignant behaviors of tumor cells but also regulates the neurologic diseases. CXCR3 and its ligands directly or indirectly contribute to neuroinflammation and neuroimmunity， and potentially serve as therapeutic targets for diseases like multiple sclerosis， Alzheimer’s disease， and glioma and so on. This review discusses the expression and impact of CXCR3 and its ligands in neurological diseases such as multiple sclerosis， neurologic tumors， neurodegenerative diseases， and neuropathic pain， as well as their associations with CXCR3 ligands. Understanding the mechanisms linking CXCR3 to these diseases could facilitate its potential as an early diagnostic biomarker and a target for drug intervention， and provide the basis of studying the occurrence and developmant of nervous system disease.

Key words: Chemokine receptor 3, CXC chemokine receptor 3 ligands, Neurological inflammation, Neurological tumor, Neurodegenerative diseases

CLC Number:

R741.02

Wenhui LIU,Miao YU,Ying GUO,Yupeng LIU,Yang XING,Xinyu HONG,Jiale CUI. Research progress in effect of CXC chemokine receptor 3 on occurrence and development of nervous system diseases[J].Journal of Jilin University(Medicine Edition), 2024, 50(5): 1474-1480.

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Research progress in effect of CXC chemokine receptor 3 on occurrence and development of nervous system diseases

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