Journal of Jilin University Medicine Edition ›› 2016, Vol. 42 ›› Issue (03): 561-564.doi: 10.13481/j.1671-587x.20160327

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Detection of Th9 cells in peripheral blood of patients with small cell lung cancer and its clinical significance

SUN Munan, FANG Yanqiu, LIU Lei, MA Yinfu, WEI Haifeng, TAN Yan   

  1. Medical Center for Diagnosis and Treatment, People's Hospital, Jilin Province, Changchun 130021, China
  • Received:2015-10-13 Published:2016-06-17

Abstract:

Objective: To detect the ratios of peripheral blood Th9 cells and the levels of serum IL-9 in the patients with small cell lung cancer (SCLC),and to investigate the effect of Th9 cells on the development of human SCLC. Methods: Twenty SCLC patients at limited stage(limited stage SCLC group),16 SCLC patients at extensive stage(extensive stage SCLC group), and 10 healthy controls (healthy control group) were selected.The ratios of Th9 cells to CD4+ cells in peripheral blood and the levels of serum IL-9 were detected by flow cytometry and ELISA, respectively. Results: Compared with healthy control group,the level of serum IL-9 of the patients in SCLC group was increased(t=4.001,P<0.01),and the levels of IL-9 of the patients in limited stage SCLC group was lower than that in extensive stage SCLC group(t=3.089,P<0.01).The ratio of Th9 cells of the patients in SCLC group was higher than that in healthy control group (t=3.731,P<0.01),and the ratio of Th9 cells of the patients in limited stage SCLC group was lower than that in extensive stage SCLC group (t=2.825,P<0.01). Conclusion: Th9 might directly promote the development of SCLC through secreting IL-9.The peripheral blood Th9 cells and IL-9 might be biomarkers to evaluate SCLC progression.

Key words: cancer,small cell lung, Th9 cell, interleukin-9, clinical stage, tumor progression

CLC Number: 

  • R734.2