羟乙基淀粉溶液对卵巢过度刺激综合征的预防作用

doi:10.13481/j.1671-587x.20160619

Abstract

Abstract:

Objective: To explore the risk factors of ovarian hyperstimulation syndrome(OHSS), and to study the intravenously injected with preventive effect of hydroxyethyl starch solution on OHSS.Methods: A randomly prospective clinical trial including 192 fertilization-embryotransfer(IVF-ET) patients with high risk of OHSS was performed in vitro,and the patients were randomly divided into experimental group(n=101) and control group(n=91).The patients in experimental group were intravenously injected with 500 mL hydroxyethyl starch solution per day during 24 h of oocyte retrieval and lasted for 3 d;the patients in control group were not treated with any drugs.The general data,the incidence of OHSS,and the incidence of moderate and severe OHSS of the patients in two groups were compared; the relative factors of moderate and severe OHSS were analyzed by Logistic regression analysis.Results: The Logistic regression analysis results showed that the smaller age and body mass index were the protective factors of OHSS (OR<1)and the higher E2 value on the human chorionic gonadotropin(HCG) injection day and the larger number of follicles taken from the oocytes(OR>1) were the risk factors of OHSS.The incidence of OHSS of the patients in experimental group was 31.68%(32/101),which included 21 cases of moderate OHSS (20.79%) and 11 cases of severe OHSS(10.89%);the incidence of OHSS in control group was 46.15%(42/91),which included 24 cases of moderate OHSS(26.37%) and 18 cases of severe OHSS(19.78%);the incidence of OHSS and severe OHSS of the patients in experimental group was significantly lower than those in control group(χ²=4.23,P<0.05;χ²=2.95,P<0.05).Conclusion: Age,body mass index,E2 value on the HCG injection day,and the number of follicles taken from the oocytes are the related factors of OHSS,and play an important role in predicting the incidence of OHSS;hydroxyethyl starch solution can markedly decrease the incidence of OHSS,and has better preventive effect on severe OHSS.

Key words: hydroxyethyl starch, high risk factor, human chorionic gonadotropin, ovarian hyperstimulation syndrome, estradiol

CLC Number:

R711.75

GUO Li, ZHANG Xiaoxia, YU Meiling, ZHAO Ting, ZHANG Liqun. Preventive effect of hydroxyethyl starch solution on ovarian hyperstimulation syndrome[J].Journal of Jilin University Medicine Edition, 2016, 42(06): 1147-1150.

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Preventive effect of hydroxyethyl starch solution on ovarian hyperstimulation syndrome

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