| [1] Ferdinandy P,Hausenloy DJ,Heusch G,et al.Interaction of risk factors,comorbidities,and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning,postconditioning,and remote conditioning[J].Pharmacol Rev,2014,66:1142-1174.
[2] Pang L,Ma H,Cai Y,et al.Inhibition of COX-2/PGE2/EP4 signaling protects against post-hypoxic apoptosis In H9C2 cardiomyocytes[J].FASEB,2016,30:937-939.
[3] Murakami M.Lipid mediators in life science[J].Exp Anim,2011,60:7-20.
[4] Harizi H,Corcuff JB,Gualde N.Arachidonic-acid-derived eicosanoids:roles in biology and immunopathology[J].Trends Mol Med,2008,14:461-469.
[5] Pang L,Cai Y,Tang EH,et al.Prostaglandin E receptor subtype 4 signaling in the heart:role in ischemia/reperfusion injury and cardiac hypertrophy[J].J Diabetes Res,2016,2016:1324347.
[6] Kobilka BK.G protein coupled receptor structure and activation[J].Biochim Biophys Acta,2007,1768:794-807.
[7] Sugimoto Y,NarumiyaS.Prostaglandin E receptors[J].Biolog Chem,2007,282:11613-11617.
[8] Yokoyama U,Iwatsubo K,Umemura M,et al.The prostanoid EP4 receptor and its signaling pathway[J].Pharmacol Rev,2013,65:1010-1052.
[9] Tuteja N.Signaling through G protein coupled receptors[J].Plant Signaling Behavior,2009,4:942-947.
[10] Delghandi MP,Johannessen M,Moens U.The cAMP signalling pathway activates CREB through PKA,p38 and MSK1 in NIH 3T3 cells[J].Cell Signal,2005,17:1343-1351.
[11] Ichiki T.Role of cAMP response element binding protein in cardiovascular remodeling:good,bad,or both?[J]. Arterioscler Thromb Vasc Biol,2006,26:449-455.
[12] Fujino H,Regan JW.EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein[J].Mol Pharmacol, 2006,69:5-10.
[13] Anand-Srivastava MB.Modulation of Gi proteins in hypertension:role of angiotensin Ⅱ and oxidative stress[J].Curr Cardiol Rev,2010,6:298-308.
[14] Fujino H,West KA,Regan JW.Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2[J].J Biol Chem,2002,277:2614-2619.
[15] Minami M,Shimizu K,Okamoto Y, et al.Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation[J].J Biol Chem,2008,283:9692-9703.
[16] He Q,Harding P,LaPointe MC.PKA,Rap1,ERK1/2,and p90RSK mediate PGE2 and EP4 signaling in neonatal ventricular myocytes[J].Am J Physiol Heart Circ Physiol,2010,298:H136-143.
[17] Qian JY,Leung A,Harding P,et al.PGE2 stimulates human brain natriuretic peptide expression via EP4 and p42/44 MAPK[J].Am J Physiol Heart Circ Physiol,2006,290:H1740-1746.
[18] Miyatake S,Manabe-Kawaguchi H,Watanabe K,et al.Prostaglandin E2 induces hypertrophic changes and suppresses alpha-skeletal actin gene expression in rat cardiomyocytes[J].J Cardiovasc Pharmacol,2007,50:548-554.
[19] LaPointe MC,Mendez M,Leung A,et al.Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse[J].Am J Physiol Heart Circ Physiol,2004,286:H1416-1424.
[20] Degousee N,Fazel S,Angoulvant D, et al.Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction[J].Circulation,2008,117:1701-1710.
[21] Qian JY,Harding P,Liu Y,et al.Reduced cardiac remodeling and function in cardiac-specific EP4 receptor knockout mice with myocardial infarction[J].Hypertension,2008,51:560-566.
[22] Xiao CY,Yuhki K,Hara A, et al.Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4[J].Circulation,2004,109:2462-2468.
[23] Hara A,Yuhki K,Fujino T, et al.Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor[J].Circulation, 2005,112:84-92.
[24] Frey N,Katus HA,Olson EN,et al.Hypertrophy of the heart:a new therapeutic target?[J]. Circulation,2004,109:1580-1589.
[25] Metrich M,Berthouze M,Morel E,et al.Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology[J].Pflugers Arch,2010,459:535-546.
[26] Frias MA,Rebsamen MC,Gerber-Wicht C,et al.Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes:A role in cardiac hypertrophy[J].Cardiovasc Res,2007,73:57-65.
[27] Mendez M,LaPointe MC.PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation[J].Am J Physiol Heart Circ Physiol,2005,288:H2111-2117.
[28] Rose BA,Force T,Wang Y.Mitogen-activated protein kinase signaling in the heart:angels versus demons in a heart-breaking tale[J].Physiol Rev,2010,90:1507-1546.
[29] Kaidi A,Qualtrough D,Williams AC,et al.Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia[J].Cancer Res,2006,66:6683-6691.
[30] He J,Wang M,Jiang Y, et al.Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1alpha/COX-2 pathway[J].Environ Health Perspect,2014,122:255-261.
[31] Abbate A,Santini D,Biondi-Zoccai GG, et al.Cyclo-oxygenase-2(COX-2) expression at the site of recent myocardial infarction:friend or foe?[J]. Heart,2004,90:440-443.
[32] Cai Z,Zhong H,Bosch-Marce M,et al.Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha[J].Cardiovasc Res,2008,77:463-470.
[33] Leineweber K,Bohm M,Heusch G.Cyclic adenosine monophosphate in acute myocardial infarction with heart failure:slayer or savior?[J]. Circulation,2006,114:365-367.
[34] Takahashi T,Tang T,Lai NC, et al.Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction[J].Circulation,2006,114:388-396.
[35] Birkenmeier K,Janke I,Schunck WH, et al.Prostaglandin receptors mediate effects of substances released from ischaemic rat hearts on non-ischaemic cardiomyocytes[J].Eur J Clin Invest,2008,38:902-909.
[36] Krijnen PA,Nijmeijer R,Meijer CJ,et al.Apoptosis in myocardial ischaemia and infarction[J].J Clin Pathol,2002,55:801-811.
[37] Frias MA,Somers S,Gerber-Wicht C,et al.The PGE2-Stat3 interaction in doxorubicin-induced myocardial apoptosis[J].Cardiovasc Res,2008,80:69-77.
[38] Frangogiannis NG.Targeting the inflammatory response in healing myocardial infarcts[J].Curr Med Chem,2006,13:1877-1893.
[39] Hishikari K,Suzuki J,Ogawa M, et al.Pharmacological activation of the prostaglandin E2 receptor EP4 improves cardiac function after myocardial ischaemia/reperfusion injury[J].Cardiovasc Res,2009,81:123-132. |
