Journal of Jilin University Medicine Edition ›› 2017, Vol. 43 ›› Issue (02): 334-338.doi: 10.13481/j.1671-587x.20170223

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Risk factors of malignant thyroid neoplasms and papillary thyroid cancer level Ⅵ lymph node metastasis

ZHAO Zhiyan1, SHENG Jindong1, LIU Baoguo1,2   

  1. 1. Department of Head-Neck Surgery, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Cancer Hospital and Institute, Peking University, Beijing 100036, China;
    2. Department of General Surgery, Aerospace Central Hospital, Beijing 100039, China
  • Received:2016-07-06 Online:2017-03-28 Published:2017-03-31

Abstract: Objective: To analyze the influencing factors associated with the malignant thyroid neoplasms and the level Ⅵ lymph node metastasis of papillary thyroid cancer(PTC),and to clarify the risk factors of the malignant thyroid neoplasms and level Ⅵ lymph node metastasis of the patients with PTC. Methods: A retrospective analysis on the materials of 99 PTC patients with routine thyroid nodular thyroid cancer resection and level Ⅵ lymph node dissection and 22 nodular goiter patients with thyroid lobectomy were performed.The PTC patients were divided into lymph node metastasis group (48 cases) and non-lymph node metastasis group (51 cases) based on the pathologic results. The associations between the clinical factors such as gender, age, tumor size, calcification, border and malignant thyroid neoplasms and the level Ⅵ lymph node metastasis of PTC were analyzed using Pearson χ2 test. Results: Gender (P=0.959, OR =0.972)had no significant correlation with malignant thyroid neoplasms,but age (P<0.05, OR= 0.341), calcification (P< 0.001, OR = 0.115) and unclear border (P< 0.001, OR = 18.947) were associated with malignant thyroid neoplasms. Gender(P=0.379, OR = 1.523), calcification(P=0.064, OR =2.649) and unclear border(P=0.536, OR =0.727)were not apparently correlated with level Ⅵ lymph node metastasis of PTC, but age (P< 0.01,OR = 3.498) and tumor size (P< 0.001, OR = 0.177) were associated with level Ⅵ lymph node metastasis in the PTC patients. Co-existence of calcification and unclear border(P=0.189, OR=1.781)had no correlation with level Ⅵ lymph node metastasis in the PTC patients. Conclusion: Age is not only a risk factor for malignant thyroid neoplasms, but also a factor associated with level Ⅵ lymph node metastasis in the PTC patients. Calcification and unclear border are also the risk factors for malignant thyroid neoplasms, but they can not determine the central compartment lymph node metastasis in the PTC patients. In addition, tumor size can be prompted to predict the level Ⅵ lymph node metastasis in the PTC patients.

Key words: border, papillary thyroid cancer, lymph node metastasis, calcification

CLC Number: 

  • R736.1