头孢哌酮钠舒巴坦钠对反复下呼吸道感染患者中性粒细胞胞外网状陷阱形成的影响

doi:10.13481/j.1671-587x.20170327

Abstract

Abstract: Objective: To detect the neutrophil extracellular traps (NETs) formation in the peripheral blood of the patients with recurrent respiratory tract infection, and to evaluate the effect of sulbactam sodium/cefoperazone sodium on the formation of NETs. Methods: A total of 36 patients with recurrent respiratory tract infection (case group) and 30 healthy volunteers (healthy control group) were selected. The NETs formation of subjects in two groups was detected by confocal microscope and scanning electron microscope (SEM). According to the appearance of neutrophils, the formation of NETs was classified as grade Ⅰ, Ⅱ and Ⅲ,the number of NETs formation cells of subjects in two groups was calculated. The formation of NETs of the patients in case group were detected before and after treated with sulbactam sodium/cefoperazone sodium. Results: The number of NETs formation cells of grade Ⅰ and Ⅱ of the patients in case group was more than that in healthy control group (P<0.05); while the number of NETs formation cells of grade Ⅲ of the patients in case group was less than that in healthy control group (P<0.05). The number of NETs formation cells of grade Ⅰ and Ⅱ of the patients in case group were significantly decreased (P<0.05), while the number of NETs formation cells of grade Ⅲ was significantly increased (P<0.05) after treated with sulbactam sodium/cefoperazone sodium. Conclusion: A lot of NETs with high antibacterial function can be formed in the patients with recurrent lower respiratory tract infection, and sulbactam sodium/cefoperazone sodium can inhibit the formation of NETs.

Key words: recurrent lower respiratory tract infection, confocal microscope, scanning electron microscope, neutrophil extracellular traps, sulbactam sodium/cefoperazone sodium

CLC Number:

R563

TANG Ying, HUANG Yuanping, JING Wenhua, GUAN Yinghui. Effect of sulbactam sodium/cefoperazone sodium on neutrophil extracellular traps of patients with recurrent lower respiratory tract infection[J].Journal of Jilin University Medicine Edition, 2017, 43(03): 607-610.

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Effect of sulbactam sodium/cefoperazone sodium on neutrophil extracellular traps of patients with recurrent lower respiratory tract infection

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