Abstract: Objective:To investigate the effect of Chinese traditional medicine-Shuanghuangbu combined with Xipayi Mouth Rinse on the periodontal indexes of the peri-implantitis patients,and to detect the curative effect of Shuanghuangbu combined with Xipayi Mouth Rinse in the treatment of peri-implantitis. Methods:A total of 40 patients diagnosed as peri-implantitis were randomly divided into control group and Chinese traditional medicine group(n=20).All of the patients received supragingival scaling and subgingival scaling, and then the peri-implant pocket of the patients in Chinese traditional medicine group were washed with Xipayi Mouth Rinse, while the fine probe slided slowly along the inner wall of peri-implant pocket into the bottom and retained the Shuanghuangbu,and retreated gently and made the medicine overflow the gingival margin.The patients in control group were given 3% hydrogen peroxide and 0.9% sodium chloride injection washed by turns. The indexes of covering modified plaque index(mPLI), probing pocket depth (PPD),modified sulcular bleeding index(mSBI) of the patients in two groups at baseline and after treatment were detected; Whatman#1 was applied to aspirate the peri-implant sulcus fluid (PISF)which were weighed at baseline and after treatment,and the level of interleukin-1β(IL-1β) in PISF was analyzed by ELISA method. Results:No differences were observed in age,sex,periodontal indexes, weights of PISF and IL-1β levels of the patients in two groups before treatment (P>0.05). Compared with before treatment,the indexes including PPD, mSBI,mPLI,weight of PISF and IL-1β level in PISF of the patients in two groups were decreased after treatment(P < 0.05).After treatment, the differences in mSBI, mPLI, weight of PISF and IL-1β level in PISF of the patients between control group and Chinese traditional medicine group were significant(P < 0.05).Compared with control group,the PPD level of the patients in Chinese traditional medicine group was decreased,but the difference was not significant(P > 0.05). Conclusion:The curative effect of Chinese traditional medicine-Shuanghuangbu combined with Xipayi Mouth Rinse is obsious,and the treatment can improve the periodontal status and reduce the level of IL-1β in PISF.

Key words: modified sulcus bleding index, peri-implantitis, Shuanghuangbu, modified plaque index, Xipayi Mouth Rinse