Abstract: Objective:To evaluate the efficacy of intravitreal lucentis or conbercept injection combined with ahmed glaucoma valve(AGV) implantation on the treatment of neovascular glaucoma(NVG). Methods:A total of 68 NVG patients(68 eyes) were divided into three groups according to the pretreatment (the intravitreal injection of lucentis or conbercept or no intravitreal injection 3-7 d before AGV implantation):lucentis group(n=26,given intravitreal injection of 10 g·L^-1 lucentis), conbercept group(n=21,given intravitreal injection of 10 g·L^-1 conbercept)and control group (n=21,given medicine or puncture of anterior chamber to smoothen the IOP and received AGV implantation). The panretina photocoagnlation(PRP) was performed in the patients with clear ocular media before intravitreal injection or AGV implantation. For the patients with cloudy ocular media,the intravitreal injection of anti-VEGF drugs was performed first and the PRP was performed when fundus could be seen. Results:Compared with before operation,the mean IOP and the number of antiglaucoma medications of the patients used in three groups after operation were significantly decreased(P < 0.01). There were no significant differences in the successful rates of operation of the patients in three groups at different time points after operation(P>0.05). 1 month and 3 months after operation,the BCVA of the patients in lucentis and conbercept groups was significantly better than that in control group(P<0.05).There were no significant differences in the incidence of complications of the pateints between lucentis and conbercept groups at different time points after operation (P>0.05). Conclusion:Intravitreal injection of anti-VEGF drugs combined with AGV implantation is effective and safe in the treatment of NVG. In short term, it can improve the vision, relieve the pain and reduce the complications.

Key words: neovascular glaucoma, conbercept, ahmed glaucoma valve, lucentis