Abstract: Objective:To evaluate the clinical effect of pereutaneous vertbroplasty(PVP) combined with implantation of iodine-125(¹²⁵I)radioactive particle in the treatment of vertebral metastasis,and to provide basis for the treatment of vertebral metastasis. Methods:A total of 69 patients with vertebral metastasis were divided into test group(n=32) and control group(n=37); the patients in test group were treated with PVP comined with implantation ¹²⁵I radioactive particle and the patients in control group were treated with PVP only. The heights of anterior and posterior vertebral bodies of the patients before and after treatment were detected by X-ray. The numerical rating scale(NRS)scores, pain relief rate and the incidence of surgical complications of the patients were recorded before operation and 1 d, 1 week, 1 month, 3 months, and 6 months after operation. Results:The operation was successfully performed in all the patients without local bleeding; there were no movement dysfunction and nerve compression phenomenon.There was no leakage of bone cement. All the ¹²⁵I radioactive particles located well and there was no particle obscission. The heights of vertebral bodies of the patients in two groups after operation were increased compared with before operation(P<0.05).The NRS scores of the patients in two groups s at 1 d, 1 week, 1 month, 3 months, 6 months after operation were significantly decreased compared with before operation(P<0.05);compared with control group,the NRS scores of the patients in test group at 1 d,1 week,1 month,3 months,6 months after operation were decreased(P<0.05).The incidence of pulmonary embolism or radiation myelitis complications was about 4.3% in 69 patients. Compared with control group, the difference in the incidence of complications of the patients in test group was not significant(P<0.05). Conclusion:PVP combined with ¹²⁵I radioactive particle implantation is a safe and effective method in the treatment of vertebral metastasis, which can relieve the pain of the patients obviously compared with PVP.

Key words: pereutaneous vertbroplasty, iodine-125(125I) radioactive particle, vertebral metastasis, numerical rating scale