Abstract: Objective:To investigate the expressions of hypoxia-inducible factor-1α (HIF-1α) and heat shock protein 70 (HSP70) in the placenta tissue of the patients with pregnancy-induced hypertension syndrome(PIH),and to elucidate the clinical significances of their expressions in the placenta tissue of the patients with PIH. Methods: Twenty-two cases of placenta tissue of the PIH patients (PIH group) and eighteen cases of placenta tissue of the normal pregnant women (control group) were selected. The expressions of HIF-1α and HSP70 were detected by immunohistochemical method.The differences of potive expressions rates of HIF-1α and HSP70 in placenta tissue of the PIH patients and the normal pregnant women and their relationships in placenta tissue of the PIH patients were analyzed. Results: The positive expression rate of HIF-1α in placenta tissue of the patients in PIH group(81.8%) was higher than that of the normal pregnant women in control group(38.9%) (χ²=7.785,P=0.005),and the positive expression rate of HSP70 in placenta tissue of the patients in PIH group (90.9%) was higher than that of the normal pregnant women in control group(55.6%) (χ²=6.599,P=0.010). Eighteen cases of placenta tissue with HIF-1α positive expression in the PIH patients had HSP70 positive expression (100.0%);among four cases of placenta tissue with HIF-1α negative expression, two cases had HSP70 negative expression (50.0%); their expressions in placenta tissue of the PIH patients had positive correlation(r=0.671,P=0.001). Conclusion: The expressions of HIF-1α and HSP70 in placenta tissue of the PIH patients are higher,and they have positive correlation.

Key words: hypoxia-inducible factor-1α, heat shock protein 70, pregnancy-induced hypertension syndrome, correlation analysis, placenta tissue