对乙酰氨基酚对早产幼鼠模型血流动力学、左心室功能和血浆脑钠肽水平的影响

doi:10.13481/j.1671-587x.20180621

Abstract

Abstract: Objective: To investigate the effects of acetaminophen on the hemodynamics, left ventricular function and plasma level of brain natriuretic peptide(BNP) in the premature young rats,and to clarify its mechanism in the treatment of patent ductus arteriosus(PDA) in the premature infants.Methods: The pregnant rats were injected intraperitoneally with lipopolysaccharide(LPS) to prepare the premature young rat models. The premature young rats were divided into model control group (n=18)and administration group (n=19);another 10 young rats with normal gestratonal age were selected and used as blank control group. The young rats in blank control group didn't receive any treatment, the young rats in model control group were not given any drug, and the premature young rats in administration group were continunously administrated with acetaminophen for 3 d. Color Doppler ultrasonography was used to detect the hemodynamic parameters of the young rats in various groups, including left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDd), left ventricular end systolic diameter (LVESd), fractional shortening (FS), left ventricular end-systolic volume (ESV), and left ventricular end-diastolic volume (EDV).The plasma BNP levels of young rats were detected.Results: The body weights of the young rats in administration group and model control group were lower than that in blank control group (P<0.05). After administration of acetaminophen for 3 d, compared with model control group, the body weight of the young rats in administration group was increased (P<0.05). Compared with model control group,the LVEF, FS and EDV of the young rats in administration group were increased (P<0.05),and the LVEDd, LVESd and ESV of the young rats were decreased(P<0.05). Compared with blank control group, the LVEF and FS of the young rats in administration group were decreased (P<0.05); the LVEDd, LVESd, EDV and ESV of the young rats were increased, but the differences were not statistically significant (P>0.05).Compared with blank control group, the plasma BNP level of the young rats in model control group was significantly increased(P=0.004);compared with model control group, the plasma BNP level of the young rats in administration group was significantly decreased(P=0.009).Conclusion: Acetaminophen can protect the left ventricular function of the young rats by improving the hemodynamic indicators and reducing the plasma BNP level.

Key words: acetaminophen, premature young rats, hemodynamics, left ventricular function, plasma brain natriuretic peptide

CLC Number:

R722

YAO Mang, HUANG Huijie, LIU Lina, FENG Lijuan. Effects of acetaminophen on hemodynamics, left ventricular function and plasma level of brain natriuretic peptide of premature young rats[J].Journal of Jilin University(Medicine Edition), 2018, 44(06): 1230-1234.

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Effects of acetaminophen on hemodynamics, left ventricular function and plasma level of brain natriuretic peptide of premature young rats

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