骨膜蛋白在慢性牙周炎患者牙龈组织中的表达及其临床意义

doi:10.13481/j.1671-587x.20190327

Abstract

Abstract: Objective:To detect the expressions of periostin, matrix metalloproteinase-8 (MMP-8)and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2)in gingival tissue of the patients with chronic periodontitis,and to explore the possible role of periostin in the occurrence and development of chronic periodontitis and its related biological mechanism. Methods:A total of 23 normal gingival tissues(control group) and 19 inflammatory gingival tissues (case group)were selected. The expressions of periostin, MMP-8 and TIMP-2 in gingival tissue of the patients in two groups were detected by immunohistochemical SP method.The correlation between the expressions of periositn and MMP-8 and TIMP-2 in gingival tissue of the patients in two groups were detected by Spearman analysis. Results:The positive expression rate of periostin in gingival tissue of the patients in case group was lower than that in control group (P<0.05). The correlative analysis results demonstrated that the expression of periostin had negative relationship with the expression of MMP-8 (r=-0.51, P<0.05) in control group, and positive relationship with the expression of TIMP-2 (r=0.50, P<0.05);in case group, the expression of periostin had negative relationship with the expression of MMP-8 (r=-0.482, P<0.05), and positive relationship with the expression of TIMP-2 (r=0.655, P<0.05). Conclusion:Periostin can be used as a preliminary indicator for maintaining the structural stability of gingival tissue, and become a research target for periodontal tissue regeneration.

Key words: chronic periodontitis, periostin, matrix metalloproteinase-8, tissue inhibitor of matrix metalloproteinase-2

CLC Number:

R781.4

JIN Quan, ZHENG Yi, XU Lishuo, HUANG Yu, MA Ning, ZHANG Li. Expression of periostin in gingival tissue of patients with chronic periodontitis and its clinical significance[J].Journal of Jilin University(Medicine Edition), 2019, 45(03): 634-638.

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Expression of periostin in gingival tissue of patients with chronic periodontitis and its clinical significance

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