Journal of Jilin University(Medicine Edition) ›› 2020, Vol. 46 ›› Issue (04): 875-880.doi: 10.13481/j.1671-587x.20200434

• Imageology • Previous Articles    

Values of 3.0T MRI PDFF and IP-OP in quantificative evaluation on fatty liver

YANG Yiming, LIU Yupin, ZHOU Dongjing, CHEN Zhiyuan, XIAO Huanming, CHI Xiaoling   

  1. Department of Radiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510210, China
  • Received:2019-07-21 Published:2020-08-20

Abstract: Objective: To explore the application values of 3.0T magnetic resonance imaging(MRI) proton density fat-fraction(PDFF) and in-phase and opposed-phase(IP-OP) in the quantitative evaluation of liver fat content,and to provide the reference for non-invasive quantitative analysis of fatty liver. Methods: A total of 34 mild fatty liver patients, 29 moderate to severe fatty liver patients and 20 non-fatty liver patients (control group) were selected.All patients were diagnosed by liver biopsy. The hepatic fat fractions(HFF) of patients were detected by MRI-PDFF and MRI-IP-OP techniques. Kruskal-Wallis test was used to compare the differences in HFF between various groups. Mann-Whitney test and Bonferroni correction were used to compare the differences of HFF between two groups. The receiver operating characteristic(ROC) curve was drawn to analyze the diagnossis efficiency of each technique to evaluate the liver steatosis. Results: There were significant differences in HFF of MRI-PDFF and MRI-IP-OP of the patients between various groups(P<0.01).The HFF of MRI-PDFF of the patients in moderate and severe fatty liver group was higher than those in control group and mild fatty liver group(P<0.01), and the HFF of the patients in mild fatty liver group was higher than that in control group(P<0.01).The HFF of MRI-IP-OP the patients in moderate and severe fatty liver group was higher than those in control group and mild fatty liver group(P<0.01), and the HFF of the patients in mild fatty liver group was higher than that in control group (P<0.05).The ROC curve showed that the areas under curve(AUC) of MRI-PDFF and MRI-IP-OP in the diagnosis of mild fatty liver were 0.931 and 0.874, respectively, and the AUC of MRI-PDFF and MRI-IP-OP in the diagnosis of moderate and severe farry liver were 0.928 and 0.913, respectively. Conclusion: For the mild and moderate to severe fatty liver, MRI-PDFF has a more higher diagnosis efficiency,and it is a accurate, reliable,and non-invasive quantitative analysis method for liver steatosis.

Key words: magnetic resonance image, fatty liver, proton density fat-fraction, in-phase and opposed-phase

CLC Number: 

  • R445.2