Abstract: Objective To discuss the anti-fatigue effects of siraitia grosvenorii fruit extracts (SGFE) on the mice with exercise fatigue and to provide basis for clinical application of SGFE. Methods 144 male ICR mice were randomly divided into control group(n=36),SGFE low dosage group(n=36),SGFE middle dosage group(n=36) and SGFE high dosage  group(n=36).The mice in control group were received an oral administration of physiological saline in a volume of 1.0 mL,and the mice in other three groups were received 1.0 mL of SGFE (100,200 and 400 mg?kg-1,once a day) for 28 d. All mice were forced to swim for 15 min each day. After 28 d,the blood,liver and gastrocnemius were collected after forced  swimming test,and the biochemical parameters related to fatigue,including blood lactic acid(BLA),blood urea nitrogen(BUN),liver glycogen,and muscle glycogen were measured.Results Compared with control group,the exhautive swimming time of the mice in SGFE  low,middle and high dosage  groups was prolonged(P<0.05),but there were no significant differences between SGFE low dosage,middle dosage and high dosage  groups (P>0.05);the levels  of BLA of mice in SGFE low dosage,middle dosage and high dosage  groups were significantly lower than that in control group(P<0.05),and the BLA levels showed  a decreasing trend with the  increase of SGFE  in SGFE  low,middle  and high dosage  groups.The levels of BUN  of mice in SGFE middle  and high dosage groups were significantly lower than that in control group (P<0.05),but there was no significantdifference between SGFE  low dosage group and control group.The levels of liver glycogen and muscle glycogen of mice in SGFE low,middle  and high dosage  groups were significantly higher than that in control group(P<0.05),and they showed a increasing trend with the increase of SGFE  dosagein   SGFE low,middle and high dosage groups. Conclusion SGFE  has significant anti-fatigue effect on the  mice with exercise fatigue.

Key words:  , siraitia grosvenorii fruit extracts, physical fatigue, blood lactic acid, blood urea nitrogen, mice,ICR