Abstract:

Abstract:Objective To study the variety, appearing time and risk factors of side effects after laser photocoagulation for retinopathy of prematurity (ROP) infa
nts and to provide basis for effectively preventing the side effects.Methods 64 ROP infants with stage 3 threshold lesion were selected and divided into side effect group(n=26) and non-side effect group (n=38) according to whether any side effects such as apnea,necrotizing enterocolitis(NEC),sepsis and gastrointestinal hemorrhage accompanied.The WBC,Hgb,PLT,CRP level, screening times, laser points,weight,corrected gestat
ional age and anaesthesia style were compared between two groups. Results 38 (59.4%) infants had no side effect after laser photocoagulation,but 26 (40.6%) infants had side effects including NEC(53.8%), apnea(23.1%),sepsis(15.4%)and gastrointestinal hemorrhage (7.7%);the side effects appeared on the (3.05±1.95) d after  photocoagulation.The WBC,Hgb,PLT,CRP level, laser points and corrected gestationalage  had no significant difference between two groups(P>0.05). However, the screening times in side effect group were more than that in non-side effect group（P<0.05) and the weight was less than in non-side effect group（P<0.05). The rate of general anesthesia in non-side effect group(26.3%) was higher than that in side effect group(15.4%)(P<0.05).
Conclusion Apnea, necrotizing enterocolitis,sepsis and gastrointestinal hemorrhage are the most common side effects  after laser photocoagulation. More screen times and less weight are the risk factors of side effects. General anesthesia could help decrease the side effect of laser photocoagulation.


Key words:  retinopathy of prematurity, laser photocoagulation, side effect