Abstract:

To investigate the association between schizophrenia and the single nucleotide polymorphism（SNP） of  HIR histone cell cycle regulation defective homolog A  (HIRA).Methods PCR-restrictive fragment length polymorphism（PCR-RFLP） was used to examine the SNP of  rs1473109（A/G） of HIRA in 216 Han core family trios of schizophrenia.Data was analyzed using family based linkage disequilibrium.
Results The distribution of   allelic and genotypic  frequencies of rs1473109 of HIRA didn’t deviate from Hardy-Weinberg equilibrium.The result of TDT indicated that rs1473109 of HIRA gene had no association with schizophreaia.There were significant relationships between the distribution of genotypic frequency of rs1473109 of HIRA gene and delusion of observation（χ²=9.310，v=2,P=0.010）,experience of being revealed (χ²=14.373，v=2,P=0.001) and incoherence of thinking (χ²=11.067，v=2,P=0.004). Conclusion  As fa
r as Chinese Han people with schizophrenia,HIRA itself or gene adjacent to it may be associated with some of positive symptoms in schizophrenia.

Key words: schizophrenia； chromosome 22q11;single nucleotide polymorphism； , HIR histone cell cycle regulation defective homolog A