Abstract:

To study the preemptive analgesia effects of flurbiprofen axetil on respiratory function in patients undergoing thoracotomy.Methods Twenty male patients undergoing thoracotomy were devided into two groups equally with ten cases each to receive either flurbiprofen axetil 5 mL (50 mg) (experiment  group) or saline 5mL(control group) 15 min before incision.At the end of the surgery both groups received intravenous sufentanyl PCA with a loading dose of 10  g,a maintenance dose of 2 g•h<^1,a bolus dose of 2 g and a lockout interval of 15  min.Age,weight,sex,history of general anaesthesia were recorded.Analgesia grades at 4，8，12，24，and 48 h after operation were accessed and  side effects(nausea and vomiting) were recorded.Total drug use,number of boluses delivered,number of boluses demanded were collected.Pulmonary function (FVC,FEV1,MMEF) was tested the day before operation,as well as at 24 and 48 h after operation.Results No differences between two groups were found for demographic data.There were also no clinically relevant differences between two groups with regard to side effects (P>0.05).Significant differences were observed in analgesia grade between two groups.Visual analogue scores (VAS) in different postoperative time points (4,8,12,24 and 48h) were lower in experiment group  than those in  control group (P<0.05).Also less bolus doses were demanded and delivered in experiment group (P<0.05).Respiratory function test in both groups was not as good as that before operation. 24 and 48 h after operation,the respiratory function test  was better in experiment  group  than that in control group, but there was no significant difference(P>0.05).Conclusion Flurbiprofen axeti1 has preemptive analgesia effects with the chosen dosage regimen in patients undergoing thoracotomy and doesn’t increase side effects.But the preemptive analgesia can’t improve postoperative respiratory function.

Key words: preemptive analgesia;flurbiprofen axetil, respiratory function;patient control intravenous anagesia;thoracotomy