Abstract:

Abstract:Objective To observe the therapeutic effect of reformed  subhibernation therapy on  status epilepticus in patients with severe viral encephalitis. Methods 96 children with severe viral encephalitis complicated by status epilepticus were randomly divied into control group and experimental group. Control group: routine treatment was given that includes anticonvulsivus, ice compress and conventional therapy. The anticonvulsivus was applied in five drugs: the same doses of  wintermin and phenergan mixed up, 10% chlorpromazine hydrochloride，luminal, valii, the drugs were delivered when convulsion occurred otherwise not. Experimental group: in addition to routine treatment  reformed subhibernation therapy was given.The anticonvulsivus drug’s was delivered in return each 4-6 h according to the drugs half life. And anticonvulsivus drugs were applied for 2 d then gotten off.The  clinical manifestation, auxiliary examination and therapeutic efficacy of patients in two groups were observed.  Results All of 96 cases were analyzed. The lotal effective rate in experimental group is higher than that  in control group (χ2=5.872，P<0.05). All the patients had no  respiratory suppression. There was no obviously side effect in  two groups. The recovery time of epilepticus,fever, headache and vomition in experimental group was significanly shorter than those in  control group(P<0.05). The symptoms of status epilepticus in experimental  group was obviously alleviated.The recovery time of paralysis of limb,coma and aphasia of patients in experimental group was shorter than that in control group (P<0.05).
Conclusion The therapeutic effect of reformed  subhibernation therapy on  staturs epilepticus in patients with severe viral encephalitis is clear and safe.

Key words: reformed subhibernation therapy； severe viral encephalitis;status epilepticus