Abstract:

Objective
To investigate the susceptibility to essential hypertension(EH) in Ningxia Hui population based on the distribution of   the polymorphisms of HLA-DQB1 in  EH population . Methods   PCR-SSP method was conducted to examine the genotypes of HLA-DQB1 in 66 healthy individuals and 84 EH patients,and the genotypic and allelic frequencies were statistically computed. Results The distribution of alleles was significantly different between two groups.The frequencies of *0301,*0401,*0601,*0604/5/6/7,*0302 in EH group were significantly higher than those in control group (P<0.01 or P<0.05).The frequencies of *0501,*0602,*0603/8,*0606,*0402,*0604/5/6/8 in EH group were significantly lower than those in control group (P<0.01 or P<0.05).Conclusion In Ningxia Hui population,allele DQB1*0301,*0401,*0601,*0604/5/6/7 and *0302 might be danger factors, while *0501,*0602,*0603/8,*0606,*0402 and *0604/5/6/8 might be resistive factors of EH.

Key words: HLA antigens;susceptibility;hypertension