J4 ›› 2010, Vol. 36 ›› Issue (1): 154-158.
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HE Na, Wu Jiang, YANG Yu-Mei
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Abstract:Objective To investigate the relationship between PON1 rs2299262 htSNP polymorphism and cerebral infarction in Chinese northern Han population,and to illustrate whether rs2299262 is a genetic marker of large artery atherosclerotic infarction.Methods A case-control study was performed including 529 cerebral infarction patients and 305 normal subjects.In addition,the cerebral infarction patients were sub-grouped into 304 large artery atherosclerotic infarction patients and 225 lacunar infarction patients based on TOAST standard.PON1 rs2299262 genotypes were determined by PCR-RFLP.Results Compared with control group,the rs2299262 T allelic frequency had significant difference in large artery atherosclerotic infarction group(P<0.05).There were no significant differences of the distribution of rs2299262 T allelic frequency between case and control groups (P>0.05).When they were divided by gender,there was no difference of the distribution of PON1 rs2299262 allelic frequency and genotypic frequency between the subgroups and control group (P>0.05).Conclusion The patients with PON1 rs2299262 T allele have a higher risk of large artery atherosclerotic infarction than without it.PON1 gene rs2299262 is probably a genetic marker of large artery atherosclerotic infarction with high risk.
Key words: brain infarction; paraoxonase1 gene; tag SNP; polymorphism,single nucleotide
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HE Na, Wu Jiang, YANG Yu-Mei. Relationship analysis between C(-262)T polymorphism of PON1 gene and cerebral infarction[J].J4, 2010, 36(1): 154-158.
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http://xuebao.jlu.edu.cn/yxb/EN/Y2010/V36/I1/154
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