Abstract:

Abstract:Objective To investigate the effectiveness and safety of administration of parecoxib-sodium on the patients with acute slightly  head injury for postoperative analgesia.  Methods  60 patients with slightly head injury,ASAⅠorⅡ,aged 18-78 years,scheduled for acute neurosurgical operation were randomly divided into two groups（n=30）:parecoxib-sodium group received intravenous parecoxib -sodium 40 mg immediately after operation and control group received intravenous equivalence saline at the same time.The tramadol hydrochloride consumption at 24 h after operation,the number of unsatisfied demand and the number of successfully delivered doses were observed,and the intensity of pain was measured using VAS scores;the adverse effects,the patients’ global evaluation of the postoperative analgesia and blood coagulation function before and after administration were recorded and compared between two groups. Results The tramadol hydrochloride consumption at 24 h after operation,the percentage of the patients who needed postoperative analgesia,and the VAS scores of the patients after operation in parecoxib-sodium group were significantly lower than those in control group(P<0.05).At the same time,the percentage of the patients in parecoxib-sodium group who considered the postoperative analgesia satisfied was higher than that in control group(P<0.05). And the percentage of patients’ adverse effects in parecoxib-sodium group was lower than that in control group(P<0.05).There was no significant difference in coagulation between parecoxib-sodium group and control group(P>0.05). Conclusion Parecoxib 40 mg given in vein after neurosurgical operation can reduce the tramadol hydrochloride consumption and improve postoperative analgesia in patients with acute slightly head injury．

Key words: parecoxib-sodium;acute slightly head injury;tramadol hydrochloride, analgesia;blood clotting function