Abstract:

Abstract:Objective To evaluate the efficacy and safety of vandenafil combined with mental intervention in aged male kidney transplant recipients with erectile dysfunction(ED).Methods        
One hundred and twenty male patients(aged more than fifty years)who had received kidney transplantations at least one year before and whose serum creatinine was under 150 μmol·L^-1 were selected randomly in the study.Their sexual function was assessed with IIEF questionnaire,and those with ED were treated with oral vardenafil combined with mental intervention for six months.The efficacy was assessed with IIEF.Its safety was appraised by measuring serum creatinine levels,creatinine clearances,liver function and concentrations of CSA and FK506.Results Seventy-eight aged men with ED received oral vardenafil combined with mental intervention for six months.IIEF score was  improved from 11.2±4.2 (before treatment)to 23.3±4.6(after treatment)（P＜0.05）;but renal function,liver function, FK506 and CSA concentrations remained unchanged.There were no significant adverse effects. Conclusion Oral vardenafil combined with mental intervention is effective and safe  for the treatment of ED in aged male kidney transplant recipients.

Key words: erectile dysfunction；vardenafil;psychotherapy;kidney transplantation