Abstract:

Abstract:Objective To   study  the levels of the population-based urinary polycyclic aromatic hydrocarbons (PAHs) metabolites,  1-hydroxypyrene glucuronide (1-OHPG) and 2-naphthol,  in polluted cities with different levels of PAHs,and to clarify the feasibility of 1-OHPG and 2-naphthol as an evaluation of PAHs pollution and health hazards on the population.Methods 60 students and their parents from the three cities (Datong,Changchun and Kunming) were chosen via cluster random sampling method to fill in questionnaire and  their urinary  1-OHPG and 2-naphthol levels were measured. Results The levels of urinary 1-OHPG in students （10.94 μmol·mol^-1±6.58  μmol·mol^-1 creatinine）and parents （5.87 μmol·mol^-1±6.87  μmol·mol^-1 creatinine）in Datong were  higher than those in Changchun (students:6.33 μmol?mol-1±8.54  μmol?mol-1 creatinine;parents:4.60 μmol·mol^-1±4.08  μmol·mol^-1 creatinine）and Kunming (students:1.90 ·mol^-1±3.57  μmol·mol^-1 creatinine;parents:1.62 μmol·mol^-1±2.44  μmol·mol^-1 creatinine）（P<0.01）.The levels of urinary 1-OHPG in students and parents in Changchun were higher than those in Kunming(P<0.01).Moreover,in the  children and their  parents,there were  no significant differences of the urinary 2-naphthol levels 　between three cities（P>0.05）. Conclusion The urinary 1-OHPG level could proper
ly represent the pollution condition of PAHs.It could be used as a biomarker to evaluate the population harm of PAHs pollution.

Key words: air pollution;biological markers;polycyclic aromatic hydrocarbons;1-hydroxyprene glucuronide;2-naphthol