Abstract:

Abstract:Objective To study the changes of hemodynamics and electrocardiogram of the acute myocardial infarction models  with blood stasis and the simple acute myocardial infarction models in rats  and elucidate the difference between the acute myocardial infarction models  with blood stasis and the simple acute myocardial infarction models in rats.
Methods Wistar rats were randomly divided into control  group,acute blood stasis models group,acute myocardial infarction and sham operation group,acute myocardial infarction models group and  acute myocardial infarction models with blood stasis group(n=12).The acute myocardial infarction models under the status of the acute blood stasis in rats were built to determine the parameters of the left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure (LVEDP),maximum left ventricular rise rate and maximum left ventricular fall rate(±dp/dt max),and the pressure of carotid artery including systolic blood pressure (SBP),diastolic blood pressure (DBP) and mean artery pressure (MAP).In addition,the parameters of electrocardiogram (ECG) including heart rate (HR) and ST segment with V5 le
ad and Ⅱlead were also measured.Results  ① When the acute myocardial infarction models with blood stasis in rats and the simple acute myocardial infarction models were comparatively studied,the results showed that there were no obvious differences between them in SBP,DBP,MAP,LVSP,LVEDP and ±dp/dt max(P>0.05);② The increasing extents of the HR and ST segment with V5 lead and Ⅱlead of the acute myocardial infarction models with blood stasis in rats were much higher than those of the simple acute myocardial infarction models(P<0.05 or P<0.01).Conclusion The obvious differences are shown on the parameters of ECG,but there are  no obvious differences in the hemodynamics when the acute myocardial infarction models with blood stasis and the simple acute myocardial infarction models are comparatively studied.The results  show that it is much reasonable to evaluate pharmacodynamics of traditional Chinese drug which treat thoracic obstruction cardialgia in the acute myocardial infarction models  with blood stasis in rats.

Key words: blood stasis;myocardial infarction;rats,Wistar;hemodynamics, electrocardiography