Abstract:

Abstract:Objective To investigate the effects of Naoshukang(NSK) capsule on the hemorheology and thrombosis in rats and elucidate its protective mechanism on brain ischemia. Methods 40 Wistar rats were randomly divided into 5 groups:control, NSK 2 g/kg, NSK 8 g/kg, NSK 16 g/kg and Buchang Naoxintong(BCNXT) 2 g/kg groups.Thrombosis time of carotid artery was observed under electrical stimulation.Another 40 Wistar rats were randomly divided into blood stasis model, NSK 2 g/kg, NSK 8 g/kg, NSK 16 g/kg and BCNXT 2 g/kg groups.The thrombus length in vitro, dry weight and wet weight, ADP-induced platelet aggregation rate, clotting time, whole blood and plasma viscosities were measured. Results Compared with control group, thrombosis  time in NSK 8 g/kg and 16 g/kg groups was significantly increased (P<0.05 or  P<0.01).Compared with blood stasis model group, the thrombus length was shortened and the dry weight and wet weight were reduced (P<0.05 or  P<0.01) in NSK 8 g/kg and 16 g/kg groups;the platelet aggregation rate (P<0.05) and whole blood and plasma viscosities were decreased (P<0.05 or  P<0.01) as well,the coagulation time was prolonged(P<0.05). Conclusion  NSK capsule can prevent thrombosis and improve the characteristics of  hemorheology in rats.

Key words: Naoshukang capsule;thrombosis;hemorheology;clotting time;rats, Wistar