Abstract:

Abstract:Objective To explore the correlation between the HLA-DRB1 alleles and the chronic hepatitis B of the Han population in Jilin province，and provide a new way for treatment and prevention of chronic hepatitis B．Methods HLA-DRB1 alleles in 398 patients with chronic hepatitis B and 838 healthy controls were analyzed by using the polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) technique.Results The frequencies of HLA-DRB1*03，09 alleles in chronic hepatitis B group were higher than those in healthy control group(6.28％ vs  3.58％，P=0.031，OR=1.805； 19.60% vs  12.17%，P=0.001，OR=1.759)．The frequencies of HLA-DRB1*04，10 and 13 alleles in chronic hepatitis B group were lower  than those in healthy control group (6.28％  vs  11.34％，P=0.005，OR=0.524；0.50%  vs  2.39%，P=0.019，OR=0.207；3.27％  vs  5.97％，P=0.044，OR=0.523)．There were no significant differences in the frequencies of the other HLA-DRB1 alleles between   chronic hepatitis B group and healthy control group(P>0.05).Conclusion The HLA-DRB1*03，09 alleles may be susceptible genes for chronic hepatitis B，and HLA-DRB1*04，10，13 alleles may be protecting gene for chronic hepatitis B of Han population in Jilin province．

Key words: chronic hepatitis B；human leukocyte antigen-DRB1；PCR-SSOP；Han nationality