Abstract:

Abstract:Objective To discuss the relationship between coagulation function and gastrointestinal hemorrhage in premature infants.Methods The prothrombin time（PT）,part-time activation thromboplastin(APTT）,thrombin time (TT),fibrinogen(Fib),D-dimer(D-D) in  132 hospitalized   premature infants with gastrointestinal hemorrhage (observation group)and 156 non-hemorrhage premature infants (control group) were detected.The difference of coagulation function between two groups was compared.Results Compared with control group,the PT,APTT,and TT in observation group were significantly increased（P<0.01）,Fib was decreased（P<0.01） and  D-D was obviously increased（P<0.01）.Conclusion The changes of coagulation function are closely related to gastrointestinal hemorrhage in premature infants and may be involved in the pathogenesis of gastrointestinal hemorrhage in premature infants.

Key words: premature infant；gastrointestinal hemorrhage；prothromin time；activated partial thromboplastin time；thrombin time；fibrinogen；D-dimer