Abstract:

Abstract:Objective To observe the change of  CD4+ T Lymphocytes in patients with H1N1 at early stage and figure out its clinical significances on the progress and therapeutic selection of H1N1. Methods The absolute counts of T lymphocyte subset from the peripheral blood samples of 48 H1N1 patients in first ten days’ duration were detected by flow cytometry,and  the serial chest CT examinations were performed. Results In all 48 clinical cases,28 cases were in normal range of CD4+ lymphocyte absolute count,whose pulmonary lesions were limited and illness condition stayed in the stability,they  didn’〖KG-*3〗t need steroid. In the other 20 cases with low level of CD4+,4 cases’ illness presented the progressive development and needed to be treated with steroid and 16 cases with lightly decreased CD4+ level which had a stable condition without treatment  with steroid. The result of  Pearson correlation analysis showed that there were negative correlations between absolute count of CD4+ cells and pulmonary lesions (r=－0.299，P<0.05) and steroid treatment (r=－0.383，P<0.05). Conclusion The lower peripheral blood CD4+ cell absolute count of H1N1 patients at early stage indicates the worse condition of pulmonary lesions. The patients with remarkable decrease of CD4+ lymphocytes are in need of treatment with steroid.

Key words: influenza A;CD4+ lymphocyte;pulmonary CT;steroid