Abstract:

Objective
                   
To investigate the expressions  of gene associated with retinoid-interferon mortality-19 (GRIM-19) and its target gene product signal transducers and activator of transcription 3(STAT3)in human duodenum carcinomas,and study their effects in occurrence and development of duodenum carcinoma.  Methods 32 specimens of duodenum carcinomas,30 specimens of duodenal gastritis and ulcer tissue were included in this study.The expressions of GRIM-19 and STAT3 protein were determined by immunohistochemistry.Results The protein expression of GRIM-19 in duodenum carcinoma tissues were obviously lower than that in duodenal gastritis and ulcer tissues (P<0.05);furthermore,the protein expression of GRIM-19 was correlated to cell differentiation(P<0.01).The protein expression of STAT3 in duodenum carcinoma tissues were obviously higher than that in duodenal gastritis and ulcer tissues (P<0.01),and the expression of STAT3 was correlated to cell differentiation and lymphatic metastasis(P<0.01).The significantly negative correlation was found between the expression of GRIM-19 and STAT3 in duodenum carcinoma tissues(r=－0.470，P<0.01). Conclusion The low expression or absence of GRIM-19 may play an important role in the tumorigenesis of duodenum carcinoma.The low expression of GRIM-19 and the high expression of STAT3 co-exist in duodenum carcinoma tissues. 

Key words: gene associated with retinoid-interferon mortality-19;signal transducers and activator of transcription 3;duodenum neoplasms;immunohistochemistry