Abstract:

Abstract:Objective To detect the rate of Chlamydia infection of ocular adnexal lymphoproliferative diseases and to investigate the relativity between ocular adnexal lymphoproliferative diseases and   Chlamydial  infection.
Methods 118　patients with  ocular adnexal lymphoproliferative diseases were selected as experiment group, and 46 cases among them  with mucosa associated lymphoid tissue(MALT) lymphoma,41 cases of  hyperplasia of reactive lymphoid tissue,31 cases of other types of lymphoma. 20 cases of samples with ocular adnexal non- lymphoproliferative
diseases were selected as    control group,including 17 cases of vascular tumor and 3 cases of  thyroid associated ophthalmopathy.Then  the method of immunofluorescence was used to detect  the Chlamydia in two groups.It was positive when it showed over ten inclusionbodies in the vision of a high-rate magnification(×1 000).Otherwise it was negative.
Results 80 cases of ocular adnexal lymphoproliferative diseases in 118 cases had positive chlamydia infection(67.79%),while there was0 case  among  20 cases of ocular adnexal non- lymphoproliferative diseases in  control group(χ2=32.262, P<0.001).There was no significant differecnce of pasitive rate of Chlamydia infection between MALT lymphoma patients and non-MALT lymphoma patients(P>0.05). Conclusion There might be a relationship between common ocular adnexal lymphoproliferative diseases and    Chlamydia infection,especially the MALT lymphoma and the hyperplasia of reactive lymphoid tissue  have higher rates of   Chlamydia infection.The detection and treatment of Chlamydia infection provide a new direction of research for the diagnosis and treatment of  ocular adnexal lymphoproliferative diseases.

Key words: ocular adnexal , lymphoproliferative diseases;Chlamydia; , immunofluorescence, mucosa associated lymphoid tissue lymphoma