Abstract:

Abstract:Objective To study the effects of long-term exposure to formaldehyde on cognition and motor function of mice,and explore the potential mechanisms.Methods  48 Kunming mice were randomly divided into 4 groups: negative control and low, middle and high dose formaldehyde groups(21.0, 42.0 and 84.0 mg/m3).The mice were exposedto formaldehyde by inspiration in a static total enclosure chamber for 12 weeks. Before exposed to formaldehyde and at 4th week, 8th week and 12th week, cognition and motor function of mice were determined.At 12th week, the mice were killed, the activities of succinate dehydrogenase(SDH),Na+-K+ ATPase and Ca2+-Mg2+ATPase in the brain tissues were detected.Results   At the test of initiative escape, the times of initiative escape in high dose group were significantly decreased compared with control group at the 12th week（P<0.05).At the test of passive escape,at the 12th week, the time of passive escape of the mice in middle dose group and high dose group was increased, and there was significant difference compared with control group（P<0.05 or P<0.01).With extending of exposure to formaldehyde, the time of passive escape had changed.At 12th week, the escaping time in high dose group was significantly increased compared with the 4th week and the 8th week（P<0.05).The   SDHactivities were decreased in form aldehyde groups, and there was significant differences between high dose group  and control group (P<0.05); the activities of Na+-K+ATPase and Ca2+-Mg2+ATPase were decreased in formaldehyde groups, but there were no significant differences compared with control group (P＞0.05).Conclusion Long-term exposure to formaldehyde can  decrease of cognition and motor function and the change of energy metabolism of brain tissue  of mice,indicating that the decrease of energy metabolism may be the potential mechanisms of decrease of cognition and motor function.

Key words: formaldehyde, cognition, succinate dehydrogenase, Na+-K+ATPase, Ca2+-Mg2+ATPase