Abstract:

To explore the association between urinary lactate/creatinine ratio and neonatal asphyxia,and to clarify the application value of urinary lactate/creatinine ratio  in forecasting the hypoxie-ischemic encephalopathy （HIE） in neonates.Methods Using case-control study design method,40 cases of neonatal asphyxia infants were selected as  asphyctic group and 40 healthy infants were used as control group.The  urinary lactate/creatinine ratio in the first day after birth,urinary N-Acetyl-β-D-glucosaminidase (NAG)/creatinine and the score of Apgar of 80 infants were detected.The relationship between the urinary lactate/creatinine ratio,urinary NAG/creatinine ratio,as well as the score of Apgar and HIE were analyzed and compared in asphyctic group and control group.Results The Apgar scores at 1 and 5 min in asphyctic group were significantly lower than those in control group (P<0.01). The urinary lactate/creatinine ratio and urinary NAG/creatinine ratio  in asphyctic group 1d after birth were significantly higher than those in control group(P<0.01). There was  significantly negative correlation between the urinary lactate/creatinine ratio and the   1-min  and 5-min Apgar scores(r=－0.636，P<0.001; r=－0.883，P<0.01),but there was a significantly positive correlation between the urinary lactate/creatinine ratio and urinary NAG/creatinine  ratio(r=0.433，P<0.01).Conclusion The urinary lactate/creatinine ratio  may have decisive roles in prognosis evaluation of neonatal asphyxia,and so as the important foundation for the prediction of HIE.
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Key words:  , neonatal asphyxia；lactic acid ；lactate-acetyl-&beta, -D-glucosaminidase；creatinine