[1] REGAZZETTI C, PERALDI P, GREMÉAUX T, et al. Hypoxia decreases insulin signaling pathways in adipocytes[J]. Diabetes, 2009, 58(1):95-103.
[2] BARLOW A D, THOMAS D C. Autophagy in diabetes:beta-cell dysfunction, insulin resistance, and complications[J]. DNA Cell Biol, 2015, 34(4):252-260.
[3] BODEN G. Obesity, insulin resistance and free fatty acids[J].Current Opinion Endocrinol, 2011, 18(2):139-143.
[4] MATULEWICZ N, KARCZEWSKA-KUPCZEWSKA M. Insulin resistance and chronic inflammation[J].Postepy Higieny I Medycyny Doswiadczalnej (Online), 2016, 70:1245.
[5] ZHANG N, CAO M M, LIU H, et al. Autophagy regulates insulin resistance following endoplasmic reticulum stress in diabetes[J].J Physiol Biochem, 2015, 71(2):319-327.
[6] MAKINEN S, SKROBUK P, NGUYEN Y H, et al. Mechanisms of insulin resistance[J].Duodecim, 2013, 129(20):2115-2122.
[7] LUMENG C N, BODZIN J L, SALTIEL A R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization[J].J Clin Invest, 2007, 117(1):175-184.
[8] MCARDLE M A, FINUCANE O M, CONNAUGHTON R M, et al. Mechanisms of obesity-induced inflammation and insulin resistance:insights into the emerging role of nutritional strategies[J].Frontiers Endocrinol(Lausanne), 2013, 4(52):134-145.
[9] XU H, BARNES G T, YANG Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance[J].J Clin Invest, 2003, 112(12):1821-1830.
[10] KEANE K N, CRUZAT V F, CARLESSI R, et al. Molecular events linking oxidative stress and inflammation to insulin resistance and beta-cell dysfunction[J].Oxidat Med Cell Longev, 2015, 15(18):181643.
[11] JIAO P, CHEN Q, SHAH S, et al. Obesity-related upregulation of monocyte chemotactic factors in adipocytes:involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways[J].Diabetes, 2009, 58(1):104-115.
[12] XIANG M, WANG P X, WANG A B, et al. Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis[J].J Hepatol, 2016, 64(6):1365-1377.
[13] CAO Y, XUE Y, XUE L, et al. Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation[J].J Hepatol, 2013, 59(6):1299-1306.
[14] WEI Y Z, CHEN K M, WHALEY-CONNELL A T, et al. Skeletal muscle insulin resistance:role of inflammatory cytokines and reactive oxygen species[J].Am J Physiol Regul Integr Comp Physiol, 2008, 294(3):R673-R680.
[15] EVERS-VAN GOGH I J, OTENG A B, ALEX S, et al. Muscle-specific inflammation induced by MCP-1 overexpression does not affect whole-body insulin sensitivity in mice[J].Diabetologia, 2016, 59(3):624-633.
[16] TSUKUMO D M, CARVALHO-FILHO M A, CARVALHEIRA J B, et al. Statement of retraction. loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance[J].Diabetes,2007, 56(2):1986-1998.
[17] CROWE S, WU L E, ECONOMOU C, et al. Pigment epithelium-derived factor contributes to insulin resistance in obesity[J].Cell Metabol, 2009, 10(1):40-47.
[18] HANDSCHIN C, SPIEGELMAN B M. The role of exercise and PGC1alpha in inflammation and chronic disease[J].Nature, 2008, 454(7203):463-469.
[19] KIM K H, LEE M S. Autophagy——a key player in cellular and body metabolism[J]. Nat Rev Endocrinol, 2014, 10(6):322-337.
[20] SINGH R, KAUSHIK S, WANG Y, et al. Autophagy regulates lipid metabolism[J]. Nature, 2009, 458(7242):1131-1135.
[21] ZHOU H, FENG L, XU F, et al. Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages:A new mechanism linking berberine to insulin resistance improvement[J].Biomed Pharmacother, 2017, 89(4):864-874.
[22] LI H, ZHOU B, XU L, et al. The reciprocal interaction between autophagic dysfunction and ER stress in adipose insulin resistance[J].Cell Cycle, 2014, 13(4):565-579.
[23] GUO Q, XU L, LI H, et al. Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress[J].Lipids Health Dis, 2017, 16(1):25-31.
[24] YANG L, LI P, FU S, et al. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance[J].Cell Metabol, 2010, 11(6):467-478.
[25] GONZALEZ C D, LEE M S, MARCHETTI P, et al. The emerging role of autophagy in the pathophysiology of diabetes mellitus[J].Autophagy, 2011, 7(1):2-11.
[26] WANG H, SUN R Q, ZENG X Y, et al. Restoration of autophagy alleviates hepatic ER stress and impaired insulin signalling transduction in high fructose-fed male mice[J]. Endocrinology, 2015, 156(1):169-181.
[27] NEMAZANYY I, MONTAGNAC G, RUSSELL R C, et al. Class Ⅲ PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling[J].Nature Communicat, 2015, 6(8):283-231.
[28] BILANGES B, ALLIOUACHENE S, PEARCE W, et al. Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism[J].Nat Commun, 2017, 8(1):1804.
[29] HE C, BASSIK M C, MORESI V, et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis[J].Nature, 2012, 481(7382):511-515.
[30] HE C, SUMPTER R, LEVINE B. Exercise induces autophagy in peripheral tissues and in the brain[J].Autophagy, 2012, 8(10):1548-1551.
[31] LIU X L, YUAN H R, NIU Y M, et al. The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice[J].Biochim Biophys Acta, 2012, 1822(11):1716-1726.
[32] KIM K H, JEONG YT, OH H, et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine[J].Nat Med, 2013, 19(1):83-92.
[33] DE LAVERA I, PAVON AD, PAZ MV, et al. The connections among autophagy, inflammasome and mitochondria[J].Curr Drug Targets, 2017, 18(9):1030-1038.
[34] YOSHIZAKI T, KUSUNOKI C, KONDO M, et al. Autophagy regulates inflammation in adipocytes[J].Biochem Biophys Res Commun, 2012, 417(1):352-357.
[35] SAITOH T, FUJITA N, JANG M H, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production[J]. Nature, 2008, 456(7219):264-268.
[36] ARROYO D S, GAVIGLIO E A, PERALTA RAMOS J M, et al. Autophagy in inflammation, infection, neurodegeneration and cancer[J].Int Immunopharmacol, 2014, 18(1):55-65.
[37] LEVINE B, MIZUSHIMA N, VIRGIN H W. Autophagy in immunity and inflammation[J]. Nature, 2011, 469(7330):323-335.
[38] MENG Q, CAI D. Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway[J].J Biol Chem, 2011, 286(37):32324-32332.
[39] WU F, WEI X, WU Y, et al. Chloroquine promotes the recovery of acute spinal cord injury by inhibiting autophagy-associated inflammation and endoplasmic reticulum stress[J].J Neurotrauma, 2018,15(4):18-23.
[40] DERETIC V, LEVINE B. Autophagy balances inflammation in innate immunity[J]. Autophagy, 2018, 36(7):1-9.
[41] LING J, KANG Y, ZHAO R, et al. KrasG12D-induced IKK2/beta/NF-kappaB activation by IL-1alpha and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma[J].Cancer Cell, 2012, 21(1):105-120.
[42] MCCORMICK J, SULEMAN N, SCARABELLI T M, et al. STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy[J].J Cell Mol Med, 2012, 16(2):386-393.
[43] LI H, YU X. Emerging role of JNK in insulin resistance[J]. Curr Diabetes Rev, 2013, 9(5):422-428.
[44] YAN H, GAO Y Q, ZHANG Y. Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease[J].Mol Med Rep, 2017, 15(1):180-186. |
