Sixty healthy male mice were randomly divided into normal group， model group， positive control group （Shengjing capsule， 700 mg·kg^－1）， low dose of PGG group （100 mg·kg^－1 PGG）， medium dose of PGG group （200 mg·kg^－1 PGG） and high dose of PGG group （400 mg·kg^－1 PGG），and there were 10 mice in each group. Except for normal group， the mice in other groups were intraperitoneally injected with 30 mg·kg^－1 cyclophosphamide to establish the oligoasthenozoospermia models.The sperm was collected from the mice in various groups. The total number， survival rate， malformation rate and motility of the sperm of the mice in various groups were examined under microscope. The morphology of the sperm of the mice in various groups was observed. The testis （double）， prostate+seminal vesicle （double）， preputial gland （double） and levator ani muscle of the mice in various groups were collected and weighed for the calculation of the organ coefficients. Hematoxylin-eosin （HE） staining was used to detect the pathomorphology of the testis tissue of the mice in various groups. The levels of serum testosterone （T）， follicle stimulating hormone（FSH），and prolactin （PRL） of the mice in various groups were measured by ELISA method.

Compared with normal group， the total number of sperm of the mice in model group was decreased （P<0.01）， the survival rate of sperm was decreased （P<0.01）， the malformation rate of sperm was increased （P<0.01）， the motility of sperm was decreased （P<0.01）， the organ coefficients of testis and prostate + seminal vesicle were decreased （P<0.05 or P<0.01）， the organ coefficients of preputial gland and levator ani muscle had no significant differences （P>0.05）， the spermatogenic cell layer thickness and spermatogenic cell layer cross-sectional area in seminiferous tubule were decreased （P<0.01），and the levels of serum T， FSH， and PRL were decreased （P<0.05 or P<0.01）. Compared with model group， the total number of sperm of the mice in medium and high doses of PGG groups were increased （P<0.05）， the survival rates of sperm were increased （P<0.01）， the malformation rates of sperm were decreased （P<0.05 or P<0.01）， the motilities of sperm were increased （P<0.05 or P<0.01）， the organ coefficients had no significant differences（P>0.05）， and the spermatogenic cell layer thickness and spermatogenic cell layer cross-sectional areas in seminiferous tubule were increased （P<0.05 or P<0.01）； the levels of serum T of the mice in Shengjing capsule group and medium and high doses of PGG groups were increased （P<0.05 or P<0.01）， the levels of serum FSH of the mice in Shengjing capsule group and different doses of PGG groups were increased （P<0.05 or P<0.01）， and the levels of serum PRL of the mice in different doses of PGG groups were increased （P<0.01）.

PGG has a dose-dependent effect； with the increasing of dosage， the efficacy is enhanced.PGG can obviously improve the spermatogenesis of the oligoasthenospermic mice， and its mechanism may be related to the increasing of serum sex hormone levels by PGG.