Abstract: Objective To investigate the effect of radix salviae milliorhize on hemodynamics of portal hypertensive rats. Methods 60 Wistar rat models with portal hypertension were induced by CCl₄. Among them 56 rats with portal hypertension were divided at random into 4 groups: radix salviae 3 d group, radix salviae 10 d group, radix salviae 15 d group, and control group. After administration, the blood flow of vena portae, superior mesenteric artery, superior mesenteric artery and pressure of vena portae, average arterial pressure were measured. Results Compared with 0.9% Natrii Chloridi control group, the blood flow of vena portae, superior mesenteric artery, superior mesenteric artery and pressure of vena portae, average artery pressure in radix salviae milliorrhize 3, 10 and 15 d groups were decreased significantly (P<0.05), but between radix salviae 3 d group and 10 d group, there were no significant differences (P>0.05). Conclusion Radix salviae milliorhize can be employed for treating portal hypertension. Radix salviae milliorrhize can decrease the blood flow and portal pressure, moreover, the effect can be enhanced with the elongation of treatment time.

Key words: portal hypertension, hemodynamics