J4 ›› 2011, Vol. 37 ›› Issue (3): 534-537.
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ZHANG Zhao-zhi,MENG Xiao-ping,WANG Li
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Abstract:Objective To investigate the changes of serum tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),matrix metalbproteinase-9 (MMP-9) and oxidized low density lipoprotein(oxLDL) levels in patients with acute coronary syndrome (ACS) and provide theoretical evidence for judgement of the nature of coronary atherosclerotic plaque.Methods 63 patients who had undergone coronary angiography were divided into ACS group including 21 cases of acute myocardial infarction (AMI) and 20 cases of unstable angina (UAP)) and normal control group(n=22). Using enzyme-linked immunosorbent test (ELISA) test, the levels of serum TNF-α,IFN-γ,MMP-9 and oxLDL were detected. Results The serum levels of TNF-α,IFN-γ,MMP-9 and oxLDL in patients with ACS were higher than those in control group(P<0.05); the serum levels of TNF-α, IFN-γ and oxLDL had no significant differences between AMI group and UAP group(P>0.05); the serum level of MMP-9 in patients with AMI was higher than that in UAP group(P<0.05). Conclusion The serum levels of TNF-α,IFN-γ,MMP-9 and oxLDL can be used to judge the nature of coronary atherosclerotic plaque;TNF-α,IFN-γ,MMP-9 and oxLDL can accelerate the progress of unsteady of coronary atherosclerotic plaque and promote plaque rupture;the serum level of MMP-9 may become an important biochemical monitoring indicator about risk stratification in patients with coronary heart disease.
Key words: tumor necrosis factor-α;interferon-γ;matrix metalloproteinase-9;oxidized low density lipoprotein;acute coronary syndrome
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ZHANG Zhao-zhi,MENG Xiao-ping,WANG Li. Detection of serum TNF-α|IFN-γ| MMP-9 and oxLDL levels in patients with acute coronary syndrome and its clinical significances[J].J4, 2011, 37(3): 534-537.
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http://xuebao.jlu.edu.cn/yxb/EN/Y2011/V37/I3/534
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