Abstract: Objective To investigate the possibility and mechanism of ¹²⁵I in treatment of glioma. Methods SHG-44 glioma cells were cultivated in vitro, the inhibitory effect of¹²⁵I on SHG-44 cell proliferation was determined by MTT method. The stereotactic method was used to establish the rat intracranial glioma model. The MRI was performed at 1st week after implantation and ²⁵I was implanted in the glioma area, the MRI was performed to measure the diameter of tumor 2 weeks after implantation. The rats were killed after 2 weeks ,PCNA gene experession was determined with immunohistological method both in control and experiment group.Results one week after implantation the glioma grew,the results of MTT method showed the growth of the SHG-44 was inhibited, ¹²⁵I inhibited the expression of PCNA gene and enlonged the rat survival period. Conclusion ¹²⁵I can inhibit the growth of glioma ,the mechanism may be concerned with its inhibitory effect on PCNA gene expression.

Key words: stereotaxic technique, ^125<, sup>Ⅰ, proliferating cell nuclear antigen, gene