Abstract: Objective: To investigate the association between single nucleotide polymorphism(SNP) of integrin α-subunit 1 (ITGA1) gene and Helicobacter pylori(H. pylori) infection, and to provide the basis for the prevention and treatment of H. pylori infection-related diseases.Methods: The blood samples of 281 examinees were detected. ELISA method was used to confirm the status of H. pylori infection in the blood of the examinees.The samples were divided into H. pylori negative group(n=159) and H. pylori positive group(n=122)according to the antibody titers. The genotypes of rs1862610, rs2432143, and rs2447867 sites in ITGA1 gene were detected by TaqMan method.The haplotype was constructed by Haploview software 4.0 and unconditional Logistic regression was used to evaluate the associations between the SNPs of alleles, genotypes and haplotypes and H. pylori infection.Results: The SNPs of rs1862610 and rs2432143 sites in ITGA1 gene were not associated with H. pylori infection(P>0.05). The SNPs of rs2447867 site in ITGA1 gene was significantly associated with H. pylori infection(P<0.05). Carrying CT genotype decreased the risk of H. pylori infection (CT vs CC:OR=0.52, 95% CI:0.31-0.86). The SNPs between rs1862610 and rs2432143 sites in ITGA1 gene had a strong linkage disequilibrium (D'=1) and formed a block. None of the haplotypes was associated with H. pylori infection(P>0.05).Conclusion: The SNP of rs2447867 site in ITGA1 gene is associated with H. pylori infection,and carrying CT genotype can decrease the risk of H. pylori infection.

Key words: Helicobacter pylori, stomach tumor, integrin, gene polymorphism, single nucleotide polymorphism