Abstract:

Abstract:Objective To investigate the anti-fatigue effect of   lycium barbarum polysaccharide(LBP)  and 1,6-fructose diphosphates (FDP) and to provide scientific basis for improving training effectiveness and race performance.
Methods 140 mice were randomly divided into saline-negative control group,LBP group (20 mg/kg),FDP group (300 mg/kg) and the 2×2 analysis variance groups.The burden swimming mice were used as animal models.The swimming time,liver glycogen,muscle glycogen,lactate dehydrogenase (LDH),superoxide dismutase (SOD),blood lactate (LAC) and blood urea nitrogen (BUN) were detected.The synergy effect of LBP and FDp was analyzed.Results  Compared with negative control group,the loading swimming time in FDP and LBP groups was prolonged (P<0.01),which indicated that they played synergy effect on swimming time.The best doses of LBP and FDP were 20 mg/kg and 300 mg?kg-1(P<0.01).The activities of LDH and SOD were increased(P<0.01) and the levels of LAC and BUN were decreased in LBP group,and the liver glycogen and muscle glycogen of  mice were increased in FDP group(P<0.01).Conclusion FDP and LBP exhibits a synergy effect on anti-fatigue,its mechanism may be related to that FDP can increase the  liver glycogen and muscle glycogen reserve of mice  which can provide more energy,and LBP can accelerate the decomposition ofmetabolites,and make mice persist more time in endurance exercise.

Key words: anti-fatigue;  , lycium barbarum polysaccharide;1,6-fructose diphosphates