非布司他治疗痛风性关节炎的疗效及其安全性评价

doi:10.13481/j.1671-587x.20170127

Abstract

Abstract:

Objective: To observe the efficacy of febuxostat in the treatment of gouty arthritis and the changes of ultrasound image of the affected joints before and after treatment.Methods: Sixty-six patients with gouty arthritis were selected and divided into febuxostat group(febuxostat 40 mg·d^-1,n=37) and allopurinol group(allopurinol 100 mg·d^-1,n=29) according to the situation of drugs.The serum uric acid(UA),lipid levels of the subjects in two groups and the changes of synovial membrane surrounding blood flows signals and ultrasound images of the affected joints before and after treatment were observed.Results: Compared with before treatment,the UA levels of patients in two groups were decreased after treatment(P<0.05);At 16,20,24 weeks, the percentages of the patients whose serum UA level reached the target value in febuxostat group was higher than that of the patients in allopurinol group(P<0.05).Compared with before treatment,the level of high density lipoprotein(HDL) in febuxostat group after treatment was increased(P=0.001);the levels of triglyceride(TG),total cholesterol(TC) and low density lipoprotein(LDL) had no significant changes(P>0.05).There were no statistically significant differences of TC,TG,LDL and HDL of the patients in allopurinol group between before and after treatment(P>0.05). Most of the UA crystal disappeared after treatment of the patients in two groups (febuxostat group 71.4%, allopurinol group 58.9%);febuxostat was better than allopurinol in dissolving UA crystal with acute gout attack.The articular effusion at acute stage of gout,joint soft tissue swelling and synovial membrane surrounding blood flow signals of the patients in two groups were improved,but there were no notably changes between two groups.There were no significant changes in chronic gout attack of the patients in two groups.Conclusion: Febuxostat can effectively reduce the UA levels of the patients with gouty arthritic, improve the performance of acute gout attack, and effectively dissolve the crystal.

Key words: febuxostat, color Doppler ultrasound, gouty arthritis

CLC Number:

R589.7

YAN Haibo, MA Ning, CUI Chunli, LIU Tao, ZHAO Ling, JIANG Zhenyu. Curative effect of febuxostat in treatment of gouty arthritis and its safety evaluation[J].Journal of Jilin University Medicine Edition, 2017, 43(01): 135-140.

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Curative effect of febuxostat in treatment of gouty arthritis and its safety evaluation

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