J4 ›› 2011, Vol. 37 ›› Issue (3): 499-504.
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ZHANG Zhao-guo,LI Jing,LIU Yan|LI Dao-lei|YU Shi-yong|LIANG Xiao-fang
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Objective To study the expressions of GRIM-19 and its target gene product STAT3 in human gastric carcinoma(GC)tissues and their clinical significances,and clarify their effects in occurrence and development of gastric carcinoma. Methods RT-PCR,immunohistochemistry dyeing and Western blotting were used to detect the mRNA and protein expressions of GRIM-19 and STAT3 in GC tissues,tissues surrounding carcinoma and normal gastric tisssues. The correlations between the expressions of GRIM-19 and STAT3 and the clinicopathologic characteristics of gastric carcinoma were analyzed statistically. Results The mRNA and protein levels of GRIM-19 in GC tissues as well as tissues surrounding carcinoma were obviously lower than those in normal tissues (P<0.01). Furthermore,the expression of GRIM-19 protein was correlated to cell differentiation and clinical stage of GC (P<0.01). In contrast,the mRNA and protein levels of STAT3 as well as tissues surrounding carcinoma in GC tissues were higher than those in normal tissues (P<0.01),and the expression of STAT3 was correlated to cell differentiation,lymphatic metastasis and clinical stage of GC(P<0.01). The significantly negative correlation was found between the expressions of GRIM-19 and STAT3 in GC tissues (r=-0.396,P<0.01). Conclusion The low expression of GRIM-19 and the high expression of STAT3 co-exist in GC tissues. It may be related to malignant transformation and abnormal proliferation of cells,which facilitates the development of GC.
Key words: stomath neoplasm;gene associated with retiroid-interferon mortality-19;signal transducer and activator of transcription 3;signal transduction pathway
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ZHANG Zhao-guo,LI Jing,LIU Yan|LI Dao-lei|YU Shi-yong|LIANG Xiao-fang. Expressions of GRIM-19 and its target gene product STAT3 |in gastric carcinoma and |their significances[J].J4, 2011, 37(3): 499-504.
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http://xuebao.jlu.edu.cn/yxb/EN/Y2011/V37/I3/499
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