Abstract:

Abstract:Objective
To study the anti-fatigue effect of the water extract of Acanthopanax senticosus fruits and its mechanism，and provide experimental basis for exploration and utilization Acanthopanax senticosus resources. Methods Acanthopanax senticosus fruits were extracted by ultrasonic method and their aqueous extract was prepared.The mouse models of anti-fatigue were randomly divided into negative control,positive control and different doses of aqneous extract from Acanthopanax senticosns fruits groups.The anti-fatigue effect of aqueous extract from Acanthopanax senticosus fruits was observed through determining the exhaustive swimming time and the contents of hepatic glycogen，muscle glycogen，superoxide dismutase (SOD),lactate dehydrogenase（LDH）,blood lactic acid(LAC) as well as blood urea nitrogen(BUN) with stamina swimming mice as animal models of anti-fatigue. Results Compared with negative control and positive control groups,the loaded swimming time of mice was prolonged in different doses groups of aqueous extract from Acanthopanax senticosus fruits（P<0.01)；and the serum LDH activity was increased and the contents of LAC and BUN were decreased after exercise(P<0.01). The levels of hepatic glycogen and muscle glycogen of postexercise mice were improved;and the more sugar for aerobic athletics was increased;the SOD activity of exercising mice was significantly improved(P<0.05).Conclusion Acanthopanax senticosus fruits have anti-fatigue effects.

Key words: Acanthopanax senticosus fruits；anti-fatigue；pharmacological action