Abstract:

Objective
To investigate the effect of trimetazine on vascular endothelial function in patients with coronary heart disease.Methods  Fifty eight patients with coronary heart disease were divided into trimetazine group (n=30) and control group(n=28).With high resolution ultrasound，flow-mediated dilation (FMD) and nitroglycerin-mediated dilation(NMD), intima-media thickness(IMT) and the change rates of FMD and NMD,velocity of systolic phase of the brachial artery were measured in control group and trimetazine group.Results The FMD,NMD,the change rates of IMT with flow-mediated and nitroglycerin-mediated,velocity of systolic phase,resistent index(RI) of the brachial artery in trimetazine group and control group had no differences before treatment (P< 0.05）.The FMD and NMD,IMT,the change rates of IMT with flow-induced and nitroglycerin-induced,velocity of systolic phase and RI in trimetazine group were significantly higher than those in control group after treatment (P<0.05),but the IMT was lower than that in control group(P<0.05).
Conclusion Trimetazine can improve the vascular endothelial function of coronary heart disease.It can relieve the damage of endotheliocytes,and revival the function of endotheliocytes.

Key words: trimetazine；coronary heart disease；endothelial function;ultrasound