Abstract:

Abstract:Objective To evaluate the correlation of thyroglobulin(Tg) with 131-iodine whole body scan(^131I-WBS) in the differentiated thyroid carcinoma(DTC) patients after thyroid ablation and  provide reference index for judging  recurrence and metastasis of DTC. Methods  596 patients with DTC were cut off partial thyroid and then undergone remanent thyroid ablation with ^131I and took thyroid hormone regularly. The serum Tg levels were measured and ¹³¹I-WBS was offered after administration of 185 MBq radioactive iodine for 24，48 and 72 h. Semiquantitative visual analysis was used to grade the extent of metastasis showed in131I-WBS．The correlation of Tg levels with ^131I-WBS scores was analyzed. Results In 596  DTC patients,64 cases were confirmed with recurrence and metastasis. In these patients,the results of Tg were positive in 63 cases and negative in 1 case;the results of ^131I-WBS were positive in 56 cases and negative in 8 cases. In 63 cases with positive Tg,^131I -WBS were also positive in 55 cases. In 56 cases of patients with positive^131I-WBS,the levels of Tg in 55 cases were also positive. Nobody was both negative in two checks. The serum Tg levels had positive correlation with ^131I-WBS scores (r=0.718-0.812，P<0.01)Conclusion The serum levels of Tg are correlated with ^131I-WBS after thyroid ablation，the raising of serum Tg level indicates massive metastasis in DTC patients，a close follow-up and proper treatment are suggested．

Key words: thyroid neoplasm;thyroglubin；iodine radioisotopes;correlation