Abstract:

Objective  To approach the effectiveness and safety of irbesarten/hydrochlorothiazide combination therapy in treating essential hypertension with Meta-analysis and provide basis for their application in clinic. Methods Computer
 search was performed using the Cochrane Central Register of Controlled Trial MBA SE(1966 to September 2010),CNKI(1979 to September 2010),WanFang(1981-2010.09）,VIP（1989-2010.09），the randomized controlled trials (RCTs) were collected,then the retrieved studies according to predefined inclusion and exclusion criteria were screened,the quality of included studies was evaluated and RevMan 4.2 software was used for Meta analysis.Results A total of 516 articles were found and 5 of which were finally included. Effectiveness:χ2=7.50，df=5，P=0.19，Z=7.23（P<0.00001），OR=2.26，95％CI［1.81，2.82］；Safety:χ2=7.82
，df=5，P=0.17，Z=1.11（P=0.27），OR=0.87，95％CI［0.68，1.11］. Conclusion Irbesarten/hydrochlorothiazide combination therapy is more effective than control group in treating essential hypertension and there is no significant difference in safety between them.

Key words: irbesarten, hydrochlorothiazide；essential hypertension；Mata-analysis