Abstract:

Abstract:Objective To study the development of Arbidol hydrochloride(Ahyd) multi-layers controlled-released preparation and evaluate its  release rate  in order to provide  the basis for Ahyd pharmacodynamics reseach. Methods Ahyd multi-layers was used  as experiment group and Ahyd single-layer as control,high performance liquid chromatography (HPLC) was used to examine releasing level of two groups for calculating parameters of  drug metabolism and bioavailability.Results Compared with Ahyd single-layer,the multi-layers controlled-released preparation had several significant advantages as below:C_max fell remarkably(P<0.01);T_max,T_1/2ka,T_1/2ke,AUC_(0-10) and (MRT) increased(P<0.01).The multi-layers preparation could maintain 12 h,its relative bioavailability reached 189.3%. Conclusion The multi-layers controlled-released preparation of Ahyd has simple technique,better stability and permanent effect,all of which have met designed requirements.

Key words: arbidol hydrochloride;  , multi-layers controlled-released preparation;release rate